Publications

Breitman, Maya, et al. "Optimization of human mesenchymal stem cells for rheumatoid arthritis: implications for improved therapeutic outcomes". ACR Open Rheumatology, vol. 4, no. 2, Feb. 2022, pp. 152-60.

Chae, Han Kyu, et al. "Efficacy and Safety of Human Bone Marrow-Derived Mesenchymal Stem Cells According to Injection Route and Dose in a Chronic Kidney Disease Rat Model". International Journal of Stem Cells, Vol. 16, No. 1, Feb. 2023, pp. 66-77.

Cheng, Lin, et al. "The protective effect of a human umbilical cord mesenchymal stem cell-derived supernatant on UVB-induced photodamage of skin". Cells, Vol. 13, No. 2, Jan. 2024, p. 156.

Cotten, Charles Michael, et al. "A Pilot Phase I Trial of Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells in Neonates With Hypoxic-Ischemic Encephalopathy". Stem Cells Translational Medicine, Vol. 12, No. 6, Jun. 2023, pp. 355-64.

Emnett, Ryan J., et al. "Evaluation of Tissue Homogenization to Support the Generation of GMP-Compliant Mesenchymal Stromal Cells from the Umbilical Cord". Stem Cells International, edited by Peter Czermak, Vol. 2016, No. 1, Jan. 2016, pp. 3274054.

Johnson, Christopher D. L., et al. "Feeder-Cell-Free and Serum-Free Expansion of Natural Killer Cells Using Cloudz Microspheres, G-Rex6M, and Human Platelet Lysate." Frontiers in Immunology, Vol. 13, Mar. 2022, pp. 803380.

Khiatah, Bashar, et al. "Intra-pancreatic tissue-derived mesenchymal stromal cells: A promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles." Stem Cell Research & Therapy, vol. 10, no. 1, Dec. 2019, p. 322.

Kim, Kwangmin, et al. "Effectiveness of Mesenchymal Stem Cell Therapy for COVID-19-Induced ARDS Patients: A Case Report." Medicina, vol. 58, no. 12, Nov. 2022, p. 1698.

Lagonda, C. A., et al. "Hypoxia Increases Vegf Secretion in Multiple Sources of Mesenchymal Stem Cell". Cytotherapy, vol. 20, no. 5, May 2018, pp. S44-45.

Lopez, Lianet, et al. "Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner In Vitro." Stem Cells International, edited by Subhadeep Roy, vol. 2023, Nov. 2023, pp. 1-20.

Ma, Lan, et al. "CD146 controls the quality of human dental pulp-derived clinical mesenchymal stem cells." Stem Cell Research & Therapy, Vol. 12, No. 1, Aug. 2021, p. 488.

Shaz, Beth H, et al. "Feasibility study of umbilical cord tissue-derived mesenchymal stromal cells in COVID-19-related acute respiratory distress syndrome". Stem Cells Translational Medicine, vol. 12, no. 4, Apr. 2023, pp. 185-93.

Shaz, Beth H., et al. "Local Manufacturing Processes Contribute to Variability in Human Mesenchymal Stromal Cell Expansion While Growth Media Supplements Contribute to Variability in Gene Expression and Cell Function: A Biomedical Excellence for Safer Transfusion (BEST) Collaborative Study". Cytotherapy, Vol. 26, No. 6, Jun. 2024, pp. 531-39.

Strecanska, Magdalena, et al. "Automated manufacturing processes and platforms for large-scale production of clinical mesenchymal stem/stromal cells". Stem Cell Reviews and Reports, vol. 21, no. 2, Feb. 2025, pp. 372-89.

Sun, Jessica M., et al. "Infusion of human mesenchymal stromal cells from umbilical cord tissue in children with autism spectrum disorder". Stem Cells Translational Medicine, vol. 9, no. 10, Oct. 2020, pp. 1137-46.

Xu, Jun, et al. "Embryonic Stem Cell-Derived Mesenchymal Stem Cells Promote Colon Epithelial Integrity and Regeneration by Elevating Circulating IGF-1 in Colitis Mice". Theranostics, vol. 10, no. 26, 2020, pp. 12204-22.

Cost-effectiveness analysis of just-in-time expansion of mesenchymal stem/stromal cells (MSCs) with PLUS™ human platelet lysate for an allogeneic clinical trial. ISCT poster presentation, Montreal, 2018

Cost-effectiveness analysis of bone marrow-derived mesenchymal stem cell and adipose-derived stem cell expansion with PLUS™ Human Platelet Lysate. Cell and gene therapy bioprocessing and commercialization poster presentation, Boston, 2017

Co-administration of first trimester umbilical cord-derived perivascular cells (FTM HUCPVCs) with endothelial progenitor cells (EPCs) results in enhanced angiogenesis, both in vitro and in vivo, compared to either cell type alone. ISCT poster presentation by Create Fertility Centre, London, 2017

Human platelet lysate (hPL) is optimal for expansion of perivascular cells from first trimester human umbilical cord for regenerative medicine applications. Poster presentation at the Canadian Society for Fertility and Andrology, Toronto, 2016

Evaluation of tissue homogenization to support the generation of GMP-compliant umbilical cord-derived mesenchymal stromal cells. Stem Cells International, Vol. 2016, Article ID 3274054, 9 pages, 2016

Human platelet lysate produced on an industrial scale for use as a replacement for fetal bovine serum in MSC cell therapies. MSC poster presentation, Cleveland, 2015

Human platelet lysate as a cell culture media supplement in conjunction with a cryoprecipitate-coated bioreactor for human mesenchymal stem cell expansion in the Quantum system. ISSCR poster presentation by Terumo BCT, Vancouver, 2014

Industrial scale clinical human platelet lysate for the isolation, expansion and cryopreservation of mesenchymal stromal cells. ISSCR poster presentation, Vancouver, 2014

Phenotypic and functional properties of bone marrow-derived mesenchymal stem cells: comparison of culture in different media supplemented with human platelet lysate or fetal bovine serum. Stem Cell Res Ther. 3(1); 6 (2012)

Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion. 24(8); 1436-1446 (2007)

Human alternatives to fetal bovine serum for the expansion of bone marrow-derived mesenchymal stromal cells. Stem Cells. 27(9); 2331-41 (2009)

Griffith, Gina L., et al. "Human Platelet Lysate Delivered via an Ocular Wound Chamber for the Treatment of Corneal Epithelial Injuries". Experimental Eye Research, vol. 206, May 2021, pp. 108493.

Nguyen, Tina Tu-Thu Ngoc, et al. "Human Platelet Lysates Stimulate in Vitro Proliferation of Human Endometrial Cells from Patients with a History of Recurrent Implantation Failure". F&S Science, Vol. 3, No. 1, Feb. 2022, pp. 64-73.

Zhang, Qingyuan, et al. "Platelet lysate functionalized gelatin methacrylate microspheres for enhancing angiogenesis in endodontic regeneration". Acta Biomaterialia, vol. 136, Dec. 2021, pp. 441-55.

Viral inactivation of pooled human platelet lysate by gamma irradiation. ISCT poster presentation, Madison, 2019

Evaluation of gamma irradiated and limited donor pool human platelet lysate for clinical cell manufacturing. ISCT poster presentation, Montreal, 2018

Irradiation methods for pathogen reduction of Xeno-Free Human Platelet Lysate. ISCT poster presentation, London, 2017

Generation of monocyte-derived dendritic cells using Xeno-Free Clinical Grade Human Platelet Lysate. ISCT poster presentation, Memphis, 2016

Human platelet lysate improves wound healing. MHSRS poster presentation, Ft. Lauderdale, 2015

Industrial scale human platelet lysate for use as a replacement for fetal bovine serum in cell manufacturing protocols. ISCT poster presentation, Las Vegas, 2015

Chang, Shih-Ching, et al. "Hypermethylation and decreased expression of TMEM240 are potential biomarkers for early detection of colorectal cancer, poor prognosis and prediction of early recurrence." Clinical Epigenetics, Vol. 12, No. 1, Dec. 2020, p. 67.

McCutcheon, Sean, et al. "Orthogonal CRISPR Screens to Identify Transcriptional and Epigenetic Regulators of Human CD8 T Cell Function". Regular and Young Investigator Award Abstracts, BMJ Publishing Group Ltd, 2023, pp. A1346-A1346.

McCutcheon, Sean R., Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, et al. ATAC-Seq, Primary human T cells overexpressing BATF3. Nov. 2023.

McCutcheon, Sean R., Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, et al. "Transcriptional and epigenetic regulators of human CD8+ T cell function identified by orthogonal CRISPR screens". Nature Genetics, vol. 55, no. 12, Dec. 2023, pp. 2211-23.

Weng, Rueyhung R., et al. "Epigenetic Modulation of Immune Synaptic-Cytoskeletal Networks Potentiates Γδ T Cell-Mediated Cytotoxicity in Lung Cancer." Nature Communications, Vol. 12, No. 1, Apr. 2021, p. 2163.

Modeling biological and economic uncertainties in the production of cell therapies through the choice of culture media supplementation. Regenerative Medicine. 13(8), 917-933 (2018)

Hoganson, David M., et al. "Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction". The Annals of Thoracic Surgery, vol. 105, no. 6, Jun. 2018, pp. 1809-18.

Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction. Ann Thorac Surg. 2018 June ; 105(6): 1809-1818.